Osteoarthritis. Issue 933 (1st July 2003)

• Record Type: Journal Article
• Authors: Haq, I; Murphy, E; Dacre, J
• Is Part Of: Postgraduate medical journal. Volume 79:Issue 933(2003)
• Page Start: 377
• Page End: 383
• Publication Date: 2003-07-01
• Subjects: osteoarthritis; COMP, cartilage oligomeric matrix protein -- COX-2, cyclo-oxygenase-2 -- IL-1/IL-6, interleukin-1/interleukin-6 -- NICE, National Institute for Clinical Excellence -- NSAIDs, non-steroidal anti-inflammatory drugs -- SF-36, short form 36 -- TNF-α, tumour necrosis factor-alpha -- WOMAC, Western Ontario and McMaster Universities osteoarthritis index; Medicine -- Periodicals; 610
• DOI: 10.1136/pmj.79.933.377
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : Osteoarthritis is a chronic degenerative disorder characterised by cartilage loss. It is extremely prevalent in society and is a major cause of disability. It is important to treat osteoarthritis effectively using a multidisciplinary approach tailored to the patient's needs. This paper reviews current thinking on the aetiology, pathogenesis, investigations, and management of osteoarthritis. The paper also discusses the challenges for developing good quality outcome measures for use in large scale multicentre clinical trials for new osteoarthritis treatments, especially disease modifying osteoarthritis drugs.