Hydroxychloroquine-induced podocytopathy mimicking Fabry disease. Issue 5 (13th May 2019)

• Record Type: Journal Article
• Authors: Serre, Justine; Buob, David; Boffa, Jean-Jacques
• Is Part Of: BMJ case reports. Volume 12:Issue 5(2019)
• Publication Date: 2019-05-13
• Subjects: renal system -- pathology -- unwanted effects/adverse reactions -- proteinurea; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2018-228876
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : Hydroxychloroquine (HCQ) is largely prescribed as an immunomodulator to prevent systemic diseases flares in patients with systemic lupus erythematous, rheumatoid arthritis, Sjogren's disease. Among reported side effects, HCQ can accumulate in lysosomes and induced phospholipidosis. Here, we report an HCQ-induced podocytopathy mimicking Fabry disease (FD). They share the same histological lesions: cytoplasmic vacuolisation of the podocytes and zebra bodies on light and electronic microscopy. FD has been ruled out by measuring enzymatic activity and genetic test. The persistence of proteinuria after immunological remission of a systemic disease treated with HCQ could suggest this HCQ-induced podocytopathy.