Microchip electrophoresis and electrochemical detection: A review on a growing synergistic implementation. (20th September 2021)

• Record Type: Journal Article
• Authors: Costa, Brenda Maria De Castro; Griveau, Sophie; d'Orlye, Fanny; Bedioui, Fethi; da Silva, José Alberto Fracassi; Varenne, Anne
• Is Part Of: Electrochimica acta. Volume 391(2021)
• Publication Date: 2021-09-20
• Subjects: Microchip -- Electrophoresis -- Amperometry -- Conductimetry -- Lab-on-chip -- Microfluidics -- Electrodes; AE auxiliary electrode -- BDD boron doped diamond -- C4D capacitively coupled contactless conductivity detector -- CA catechol -- CB-NPs carbon black nanoparticle -- CCD contactless conductivity detector -- CE capillary electrophoresis -- CF carbon fiber, -- CFNE carbon fiber nanoelectrodes -- CI carbon ink -- CNT carbon nanotube electrodes -- CP carbon paste -- CV cyclic voltammetry -- CySNO S-nitrosocysteine -- CZE capillary zone electrophoresis -- DA dopamine -- DPV differential pulse voltammetry -- EC electrochemical -- EDS energy dispersive X-ray spectra -- EOF electroosmotic flow -- FE-SEM field emission scanning electron microscope -- GC glass carbon -- GO graphene oxide -- GSNO S-nitrosoglutathione -- HbaA1c mAb anti-human hemoglobin-A1c antibody -- HTGC heat-treated glassy carbon -- LC liquid chromatography -- LOD limit of detection -- LSV linear sweep voltammetry -- MCE microchip capillary electrophoresis -- MD microdialysis -- MW multi-walled -- ORMOCERs organically modified ceramic polymers -- PC polycarbonate -- PDMS polydimethylsiloxane -- PMMA polymethyl methacrylate -- POC point-of-care -- PPF pyrolyzed photoresist film -- PVAc poly(vinyl acetate) -- RE reference electrode -- RMS root mean square -- RSD relative standard deviation -- RSNO S-nitrosothiols -- S/N signal-to-noise -- SEM scanning electron microscopy -- SW single-walled -- Tg glass transition temperature -- WE working electrode; Electrochemistry -- Periodicals; Electrochemistry, Industrial -- Periodicals; 541.37
• DOI: 10.1016/j.electacta.2021.138928
• Languages: English
• ISSNs: 0013-4686

Abstract

Abstract: Microchip capillary electrophoresis (MCE) with integrated electrodes to perform electrochemical (EC) sensing is a powerful tool for fundamental research and practical applications that are increasingly in demand. In this critical review, we discuss the main strategies developed over the last twenty years to design complete MCE-EC devices. First, we outline all the questions raised by the pioneering research groups regarding the coupling of these two techniques in microfluidic devices. Then, we present all the key-solutions, in the form of strategies, that our colleagues have cleverly elaborated to make these devices evolve into elaborate and relevant tools. These evolutions have mainly focused on the nature of the electrodes used, their configuration, the process of their fabrication, their integration and positioning in the microfluidic systems and their performance within the integrated devices. Particular attention is paid to the adequacy of the materials of the microsystems and the electrodes and to the resolution of the electrical interference between the electric fields necessary for the electrophoretic separation and the electrochemical detection. Finally, we describe significant examples of methodologies for the analysis of complex biological, food and environmental samples, highlighting the analytical improvements brought by these MCE-EC systems.