Cancer-associated retinopathy with retinal phlebitis. Issue 12 (December 1993)

• Record Type: Journal Article
• Authors: Ohnishi, Y; Ohara, S; Sakamoto, T; Kohno, T; Nakao, F
• Is Part Of: British journal of ophthalmology. Volume 77:Issue 12(1993)
• Page Start: 795
• Page End: 798
• Publication Date: 1993-12
• Subjects: Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.77.12.795
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : A 50-year-old man with cancer-associated retinopathy was investigated using light and electron microscopy, immunofluorescence studies, and western blotting. He had visual disturbance, ring-like scotoma, and night blindness bilaterally. There were narrowed retinal arterioles and dilated retinal venules. Oral corticosteroid therapy had positive effects. Immunostaining using the patient's serum revealed a positive reaction in the ganglion cell layer of normal retina. Western blotting showed that the patient's serum antibody reacted with normal retinal proteins of 24 and 48 kDa. Multiple metastases were evident at autopsy.