Dose related growth response to indometacin in Gitelman syndrome. Issue 6 (1st December 1999)

• Record Type: Journal Article
• Authors: Liaw, Lynster C T; Banerjee, Kaushik; Coulthard, Malcolm G
• Is Part Of: Archives of disease in childhood. Volume 81:Issue 6(1999)
• Page Start: 508
• Page End: 510
• Publication Date: 1999-12-01
• Subjects: Gitelman syndrome -- Bartter syndrome -- indometacin -- height -- growth; Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.81.6.508
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Growth failure is a recognised feature of Gitelman syndrome, although it is not as frequent as in Bartter syndrome. Indometacin is reported to improve growth in Bartter syndrome, but not in Gitelman syndrome, where magnesium supplements are recommended. This paper presents 3 sisters with Gitelman syndrome who could not tolerate magnesium supplements, and whose hypotension and polyuria were eliminated by taking 2 mg/kg/day indometacin, but who grew poorly. However, increasing the indometacin dose to 4 mg/kg/day improved their growth significantly, without changing their symptoms or biochemistry. Gastrointestinal haemorrhage necessitated the use of misoprostol.