Endometrial stromal tumours revisited: an update based on the 2014 WHO classification. Issue 5 (16th January 2015)

• Record Type: Journal Article
• Authors: Ali, Rola H; Rouzbahman, Marjan
• Is Part Of: Journal of clinical pathology. Volume 68:Issue 5(2015)
• Page Start: 325
• Page End: 332
• Publication Date: 2015-01-16
• Subjects: UTERUS -- GYNAECOLOGICAL PATHOLOGY -- HISTOPATHOLOGY; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jclinpath-2014-202829
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Endometrial stromal tumours (EST) are rare tumours of endometrial stromal origin that account for less than 2% of all uterine tumours. Recent cytogenetic and molecular advances in this area have improved our understanding of ESTs and helped refine their classification into more meaningful categories. Accordingly, the newly released 2014 WHO classification system recognises four categories: endometrial stromal nodule (ESN), low-grade endometrial stromal sarcoma (LGESS), high-grade endometrial stromal sarcoma (HGESS) and undifferentiated uterine sarcoma (UUS). At the molecular level, these tumours may demonstrate a relatively simple karyotype with a defining chromosomal rearrangement (as in the majority of ESNs, LGESSs and YWHAE -rearranged HGESS) or demonstrate complex cytogenetic aberrations lacking specific rearrangements (as in UUSs). Herein we provide an update on this topic aimed at the practicing pathologist.