Liver function in septic shock. Issue 11 (November 1982)

• Record Type: Journal Article
• Authors: Banks, J G; Foulis, A K; Ledingham, I M; Macsween, R N
• Is Part Of: Journal of clinical pathology. Volume 35:Issue 11(1982)
• Page Start: 1249
• Page End: 1252
• Publication Date: 1982-11
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.35.11.1249
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Serum liver function tests were estimated in 57 patients admitted to an Intensive Therapy Unit (ITU) with a diagnosis of septic shock. Following an initial biochemical disturbance, persisting hyperbilirubinaemia was associated with a poor prognosis. Post-mortem liver histology in 22 patients showed varying degrees of non-specific reactive change, venous congestion, ischaemic necrosis, fatty change and intrahepatic cholestasis in 16 cases. In the remaining six cases there was moderately severe cholestasis with inspissated bile in the cholangioles. The possible aetiology of the observed cholestasis is discussed.