Clostridium difficile disease in solid organ transplant recipients: a recommended treatment paradigm. Issue 4 (August 2020)

• Record Type: Journal Article
• Authors: Wong, Darren; Nanda, Neha
• Is Part Of: Current opinion in organ transplantation. Volume 25:Issue 4(2020:Aug.)
• Publication Date: 2020-08
• Subjects: Clostridium difficile -- Clostridium difficile infection -- diarrhea -- organ transplant; Transplantation of organs, tissues, etc -- Periodicals; Immunosuppression -- Periodicals; Transplantation immunology -- Periodicals; 617.954
• DOI: 10.1097/MOT.0000000000000778
• Languages: English
• ISSNs: 1087-2418

Abstract

Abstract : Purpose of review: Organ transplant recipients have an increased incidence of Clostridium difficile disease and lower clinical response rates compared with the general population. Transplant specific treatment approaches are not defined. Therefore, a review of therapeutics in the transplant population is needed. Recent findings: A literature review on the current therapies for C. difficile was performed focusing on the evidence in transplant recipients and immunosuppressed populations. Summary: Transplant patients warrant an aggressive approach to treatment. The authors propose a suggested treatment paradigm for therapy.