A Case of Childhood Blastic Phase Chronic Myeloid Leukemia With Minor BCR-ABL. Issue 6 (August 2020)

• Record Type: Journal Article
• Authors: Yamanaka, Junko; Shimizu, Mariko; Sato, Maho; Inoue, Masami; Matsui, Motohiro; Shimada, Hiroyuki; Shichino, Hiroyuki
• Is Part Of: Journal of pediatric hematology/oncology. Volume 42:Issue 6(2020)
• Publication Date: 2020-08
• Subjects: minor BCR-ABL fusion gene transcription -- chronic myeloid leukemia -- blastic phase -- tyrosine kinase inhibitor -- reduced-intensity hematopoietic stem cell transplantation; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000001488
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Chronic myeloid leukemia (CML) is commonly associated with major BCR-ABL transcript. We present a child with blastic phase CML associated with minor BCR-ABL transcript without prior CML diagnosis. Diagnosis was achieved by fluorescence in situ hybridization of peripheral blood neutrophils, which identified 90% as BCR-ABL positive. The patient received chemotherapy with imatinib followed by dasatinib and underwent reduced-intensity hematopoietic allogeneic stem cell transplantation with prophylactic posttransplant dasatinib for 2 years and has remained in complete molecular remission. Our intensified treatment regimen was effective compared with previous studies on minor BCR-ABL CML describing inferior outcomes with tyrosine kinase inhibitor therapy.