Cross hepatotoxicity between tricyclic antidepressants. Issue 6 (June 1986)

• Record Type: Journal Article
• Authors: Larrey, D; Rueff, B; Pessayre, D; Danan, G; Algard, M; Geneve, J; Benhamou, J P
• Is Part Of: Gut. Volume 27:Issue 6(1986)
• Page Start: 726
• Page End: 727
• Publication Date: 1986-06
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.27.6.726
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Cross hepatotoxicity between drugs in very uncommon. We report the case of a patient in whom acute hepatitis was induced by a tricyclic antidepressant, amineptine, and recurred early after administration of another tricyclic antidepressant, clomipramine. This observation suggests that the tricyclic ring is involved in the mechanism of the deleterious effect of both drugs to the liver.