A Chinese familial growth hormone deficiency with a deletion of 7.1 kb of DNA. Issue 3 (March 1990)

• Record Type: Journal Article
• Authors: He, Y A; Chen, S S; Wang, Y X; Lin, X Y; Wang, D F
• Is Part Of: Journal of medical genetics. Volume 27:Issue 3(1990)
• Page Start: 151
• Page End: 154
• Publication Date: 1990-03
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.27.3.151
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : Using restriction endonuclease analysis and a human growth hormone cDNA probe, we have found a Chinese family with a human growth hormone gene deletion. Two affected sibs are homozygous for a deletion of approximately 7.1 kb of DNA, which contains the normal human growth hormone gene. The patients' parents and grandmothers are heterozygous for the deleted gene. Their grandfathers are normal and homozygous for the hGH-N gene. All of them have normal stature.