EVALUATION OF SURGICAL FACTORS AFFECTING VITREOUS HEMORRHAGE FOLLOWING PORT DELIVERY SYSTEM WITH RANIBIZUMAB IMPLANT INSERTION IN A MINIPIG MODEL. Issue 8 (August 2020)

• Record Type: Journal Article
• Authors: Bantseev, Vladimir; Schuetz, Chris; Booler, Helen S.; Horvath, Joshua; Hovaten, Kristof; Erickson, Signe; Bentley, Ellison; Nork, T. Michael; Freeman, William R.; Stewart, Jay M.; Barteselli, Giulio
• Is Part Of: Retina. Volume 40:Issue 8(2020)
• Publication Date: 2020-08
• Subjects: vitreous hemorrhage -- animal surgical model -- Port Delivery System -- anti–vascular endothelial growth factor -- retinal disease; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000002614
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To develop an animal model of vitreous hemorrhage (VH) to explore the impact of surgical parameters on VH associated with insertion of the Port Delivery System with ranibizumab (PDS) implant. Methods: Ninety eyes from 45 treatment-naive male Yucatan minipigs received PDS implant insertion or a sham procedure. The effect of prophylactic pars plana hemostasis, scleral incision length, scleral cauterization, surgical blade type/size, and viscoelastic usage on postsurgical VH was investigated. Results: Postsurgical VH was detected in 60.0% (54/90) of implanted eyes. A systematic effect on VH was only detected for pars plana hemostasis before the pars plana incision. The percentage of eyes with VH was 96.6% (28/29) among eyes that did not receive prophylactic pars plana hemostasis and 42.4% (24/58) among eyes that did. There was no VH in eyes that received laser ablation of the pars plana using overlapping 1, 000-ms spots; pars plana cautery or diathermy was less effective. The majority of all VH cases (83.3% [45/54]) were of mild to moderate severity (involving ⩽25% of the fundus). Conclusion: In this minipig surgical model of VH, scleral dissection followed by pars plana laser ablation before pars plana incision most effectively mitigated VH secondary to PDS implant insertion. Abstract : Supplemental Digital Content is Available in the Text.This minipig model of vitreous hemorrhage demonstrated that scleral dissection followed by thorough laser ablation of the pars plana before the pars plana incision could mitigate vitreous hemorrhage during Port Delivery System with ranibizumab implant insertion surgery.