Distribution of vitamin B12 R-binder in carcinomas of the digestive tract. Issue 3 (March 1988)

• Record Type: Journal Article
• Authors: Kudo, H; Ohshio, G; Ogawa, K; Kim, Y C; Wakatsuki, Y; Nakashima, Y; Yamabe, H; Inada, M
• Is Part Of: Journal of clinical pathology. Volume 41:Issue 3(1988)
• Page Start: 320
• Page End: 323
• Publication Date: 1988-03
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.41.3.320
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : To evaluate whether the increase in serum transcobalamin I, seen in patients with carcinoma, is caused by synthesis of R-binder to tumour cells, the distribution of vitamin B12 R-binder in 125 malignant growths of the digestive tract was studied. Positive staining for R-binder with immunoperoxidase was observed in 85 (70%) carcinomas. Positive staining for R-binder was observed in all four cholangiocarcinomas studied, but was absent in nine hepatocellular carcinomas. These findings suggest that determination of R-binder in liver tumours may be of some value in differentiating hepatocellular carcinomas and cholangiocarcinoma, and that synthesis of R-binder by tumour cells causes an increase in serum transcobalamin I.