Recent advances in understanding the mechanisms of PM2.5-mediated neurodegenerative diseases. (1st September 2020)

• Record Type: Journal Article
• Authors: Zhu, Xiaozheng; Ji, Xintong; Shou, Yikai; Huang, Yilu; Hu, Yu; Wang, Huanhuan
• Is Part Of: Toxicology letters. Volume 329(2020)
• Page Start: 31
• Page End: 37
• Publication Date: 2020-09-01
• Subjects: PM2.5 -- Neurodegenerative disease -- Neuroinflammation -- Oxidative stress -- Mitochondrial dysfunction -- Neuronal apoptosis; Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2020.04.017
• Languages: English
• ISSNs: 0378-4274

Abstract

Abstract: PM2.5 particles are widely believed to be associated with respiratory and cardiovascular diseases. However, recent studies have reported that PM2.5 may be associated with neurodegenerative diseases. The exact mechanism by which PM2.5 mediates neurotoxicity and cognitive dysfunction is still unclear. In the current work, we collected evidence supporting the association between PM2.5 exposure and development of neurodegenerative disorders. Evidence from epidemiological investigations, animal experiments, and ex vivo cell experiments showed that PM2.5 exposure may lead to neuroinflammation, oxidative stress, mitochondrial dysfunction, neuronal apoptosis, synaptic damage and ultimately neurodegenerative diseases.