A Practical Electrochemical Sensor for Atenolol Detection Based on a Graphene Oxide Composite Film Doped with Zinc Oxide Nanoparticles. Issue 28 (30th July 2020)

• Record Type: Journal Article
• Authors: Ayan, Ebru Mavioğlu; Karabiberoğlu, Şükriye Ulubay; Dursun, Zekerya
• Is Part Of: ChemistrySelect. Volume 5:Issue 28(2020)
• Page Start: 8846
• Page End: 8852
• Publication Date: 2020-07-30
• Subjects: activation energy -- atenolol -- pharmaceutical tablet -- Zn-GO modified electrode; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202001019
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Zinc oxide nanoparticles doped graphene oxide modified glassy carbon electrodes (Zn‐GO/GCE) were fabricated for easy, cheap and practical detection of atenolol (ATE). The morphological and chemical characterizations of modified electrodes were carried out with scanning electron microscopy (SEM), electron diffraction spectroscopy (EDS) and X‐Ray photoelectron spectroscopy (XPS). The amounts of the electrode modifiers and the differential pulse voltammetric parameters were optimized due to exhibited the best analytical response towards the determination of ATE. As a result, the calibration curves of ATE were obtained at Zn‐GO/GCE using DPV technique with two different linear parts: 7.8 ‐ 84 μmol L −1 and 167 μmol L −1 ‐ 639 μmol L −1 . The detection limit (LOD) was also calculated as 2.50 μmol L −1 . The fabricated electrode in this study is selective for ATE in the presence of some electroactive molecules. The practical, easy and cheap modified electrode was applied for the detection of ATE in atenolol medicine tablets with good recovery. Abstract : In this study, graphene oxide was synthesized by adapted Hummer's method. The graphene oxide modified glassy carbon electrode was prepared by drop‐dry method. Zinc oxide nanoparticles were easily and economically deposited by Chronoamperometric method on graphene oxide nano sheets. The developed sensor was characterized by scanning electron microscopy, electron diffraction spectroscopy and X‐Ray photoelectron spectroscopy techniques. The practical, easy and cheap modified electrode was applied for the detection of atenolol in atenolol medicine tablets with good recovery. Zinc oxide‐graphene oxide composite could potentially be applied as an effective electrode material for the atenolol determination