Dopamine agonists suppress visual-cortical reflex myoclonus. Issue 12 (December 1985)

• Record Type: Journal Article
• Authors: Obeso, J A; Artieda, J; Tuñón, T; Luquin, M R; Martínez Lage, J M
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 48:Issue 12(1985)
• Page Start: 1277
• Page End: 1283
• Publication Date: 1985-12
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.48.12.1277
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Two patients with a diagnosis of olivo-ponto-cerebellar atrophy developed cortical reflex myoclonus to visual (flash) and somaesthetic stimuli. Oral treatment with levodopacarbidopa (1000/100 mg) or subcutaneous administration of apomorphine (1 mg) abolished the visually-triggered myoclonus, without modifying reflex myoclonus to electrical or tactile stimulation. Intravenous administration of lisuride (0.1 mg) produced a marked reduction in both types of reflex myoclonus. These results indicate a selective inhibitory effect of dopamine agonist drugs on visual reflex myoclonus of cortical origin.