Germline mutation of microRNA-125a is associated with breast cancer. Issue 5 (1st May 2009)

• Record Type: Journal Article
• Authors: Li, W; Duan, R; Kooy, F; Sherman, S L; Zhou, W; Jin, P
• Is Part Of: Journal of medical genetics. Volume 46:Issue 5(2009)
• Page Start: 358
• Page End: 360
• Publication Date: 2009-05-01
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.2008.063123
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : MicroRNAs (miRNAs) are small non-coding RNAs that inhibit expression of specific target genes at the posttranscriptional level. MiRNAs are often found to be misregulated in human cancer, and they can act as either potent oncogenes or tumour suppressor genes. Here we show that a germline mutation in mature miR-125a is highly associated with breast cancer tumorigenesis, suggesting that miR-125a is likely to function as a tumour suppressor gene in human cancer.