B(C6F5)3‐Catalyzed Hydroarylation of Terminal Alkynes with Phenols. Issue 16 (22nd July 2021)

• Record Type: Journal Article
• Authors: Zhou, Jiaming; Huang, Jin; Lu, Changhui; Jiang, Huanfeng; Huang, Liangbin
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 16(2021)
• Page Start: 3962
• Page End: 3967
• Publication Date: 2021-07-22
• Subjects: B(C6F5)3 -- 2-gem-vinylphenols -- alkynes -- phenols; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202100590
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: We developed a B(C6 F5 )3 catalyzed hydroarylation of terminal alkynes with various phenols at room temperature without adding any additives, leading to the synthesis of 2‐ gem ‐vinylphenols with good regio‐selectivity. Those transformations featured a broad substrate scope with moderate yields. Mechanism studies indicated that those transformations proceeded through the activation of phenol by B(C6 F5 )3 with subsequent protonation of alkyne/Friedel‐Crafts‐type reaction. Abstract :