Association of FGF‐19 and FGF‐21 levels with primary sarcopenia. Issue 10 (17th August 2021)

• Record Type: Journal Article
• Authors: Bag Soytas, Rabia; Suzan, Veysel; Arman, Pinar; Emiroglu Gedik, Tugce; Unal, Damla; Cengiz, Mahir; Bolayirli, Ibrahim Murat; Suna Erdincler, Deniz; Doventas, Alper; Yavuzer, Hakan
• Is Part Of: Geriatrics and gerontology international. Volume 21:Issue 10(2021)
• Page Start: 959
• Page End: 962
• Publication Date: 2021-08-17
• Subjects: biomarker -- FGF‐19 -- FGF‐21 -- older adults -- sarcopenia; Geriatrics -- Periodicals; Gerontology -- Periodicals; Geriatrics -- Japan -- Periodicals; Gerontology -- Japan -- Periodicals; 618.97
• DOI: 10.1111/ggi.14263
• Languages: English
• ISSNs: 1444-1586

Abstract

Abstract : Aim: Serum fibroblast growth factor (FGF)‐19 and FGF‐21 levels have been reported to be associated with muscle hemostasis. This study aims to explore the relationship between the levels of these markers and sarcopenia. Methods: In our single‐center, cross‐sectional study, patients over 65 years old presenting to the geriatric outpatient clinic were included. Patients with secondary sarcopenia were excluded. The Strength–Assistance with walking–Rising from a chair–Climbing stairs and Falls (SARC‐F) questionnaire was applied to all patients. Sarcopenia was determined by handgrip strength (HGS), bioelectrical impedance analysis and 6‐m walk test. Serum samples were stored at −80°C until measurement. The ELISA method was used to assess FGF‐19 and FGF‐21 levels. Results: In total, 88 patients (54 women) were included. There were 43 patients in the sarcopenia group and 45 patients without sarcopenia in the control group. In those with sarcopenia, FGF‐19 was lower ( P = 0.04) and FGF‐21 was higher ( P = 0.021). There was a direct correlation between FGF‐19 with SARC‐F and HGS ( P = 0.04, B = 0.178, P = 0.006, B = 0.447) while FGF‐21 was inversely correlated with HGS and positively correlated with 6‐m walking time ( P = 0.016, B = −0.428, P = 0.004, B = 0.506). Conclusions: Our results reveal that low FGF‐19 and high FGF‐21 may be associated with sarcopenia and this finding could be explained by the impacted muscle strength. Geriatr Gerontol Int 2021; 21: 959–962 .