Prognostic value of cardiopulmonary exercise test after heart transplantation. Issue 8 (28th June 2021)

• Record Type: Journal Article
• Authors: Iglesias, Diego; Masson, Walter; Barbagelata, Leandro; Rossi, Emiliano; Mora, Mishel; Cornejo, Guillermo; Lagoria, Juan; Belziti, Cesar; Vulcano, Norberto; Marenchino, Ricardo; Pizarro, Rodolfo; Ventura, Hector
• Is Part Of: Clinical transplantation. Volume 35:Issue 8(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-06-28
• Subjects: Cardiopulmonary exercise testing -- heart transplantation -- oxygen consumption -- oxygen pulse -- predicted oxygen consumption; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.14387
• Languages: English
• ISSNs: 0902-0063

Abstract

Abstract: Background: The clinical utility of cardiopulmonary exercise testing (CPET) has not been extensively studied yet in heart transplantation (HTX) patients. Objective: To analyze the predictive value of the CPET on hospitalizations and mortality in HTX recipients. Methods: A retrospective cohort was performed from a secondary database. Patients > 18 years with HTX who underwent a CPET between 3 and 12 months after transplantation were included. Time to the first primary endpoint (HTX‐related hospitalization) was analyzed and adjusted using Cox proportional hazards regression model. Results: A total of 122 patients (mean age 50.1 years, 77.0% men) were included. Fifty‐seven patients (46.7%) had the primary endpoint. Peak VO2 (HR .95; CI 95% .90–.99, P = .03), oxygen pulse (HR .57; CI 95% .34–.96, P = .03) and predicted VO2 (HR .97; CI 95% .96–.99, P = .002) were associated with the endpoint. We did not find a significant association between the other variables and the outcome. Conclusion: In HTX recipients, peak VO2, oxygen pulse, and predicted VO2 were independently associated with hospitalizations at follow up.