TFG: a novel regulator of ULK1-dependent autophagy. (4th July 2021)

• Record Type: Journal Article
• Authors: Cecconi, Francesco; Nazio, Francesca
• Is Part Of: Molecular & cellular oncology. Volume 8:Number 4(2021)
• Publication Date: 2021-07-04
• Subjects: ULK1 -- ERGIC -- TFG -- omegasome -- neurological disorders; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2021.1945895
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C) interaction to modulate omegasome and autophagosome formation. Defective TFG-mediated autophagy could thus be postulated as a possible contributor to ontogenesis or progression of TFG-related diseases.