Activity of cinnamaldehyde, carvacrol and thymol combined with antifungal agents against Fusarium spp. Issue 5 (3rd September 2021)

• Record Type: Journal Article
• Authors: Venturini, Tarcieli Pozzebon; Rossato, Luana; Chassot, Francieli; De Azevedo, Maria Isabel; Al-Hatmi, Abdullah M. S.; Santurio, Janio Morais; Alves, Sydney Hartz
• Is Part Of: Journal of essential oil research. Volume 33:Issue 5(2021)
• Page Start: 502
• Page End: 508
• Publication Date: 2021-09-03
• Subjects: Cinnamaldehyde -- carvacrol -- thymol -- antifungal agents -- Fusarium spp; Essences and essential oils -- Periodicals; Oils, Volatile -- Periodicals; Plant Oils -- Periodicals; 547.71
• DOI: 10.1080/10412905.2021.1923580
• Languages: English
• ISSNs: 1041-2905

Abstract

ABSTRACT: Fusarium spp. are able to cause a wide range of opportunistic infections in both immunocompromised and immunocompetent individuals. Thus, new therapeutic options should be considered. We evaluated the antifungal activity of three phytocompounds (cinnamaldehyde, CIN; carvacrol, CRV; and thymol, THY), as well as their activities when combined with amphotericin B (AMB), caspofungin (CAS), itraconazole (ITC) and voriconazole (VRC) against 20 clinical isolates of Fusarium . Broth microdilution (M38-A2) and checkerboard methodologies were used to obtain MICs (Minimum inhibitory concentration) and FICIs (Fractional Inhibitory Concentration Index), respectively. The MICs observed for the phytocompounds were: 20–80 for CIN, 40-> 320 for CRV and 40–320 µg/mL for THY. The most effective combinations (synergism rates) were: THY + CAS (96%), CRV + CAS (88%), THY + AMB (76%), CRV + AMB (68%), THY + VRC (68%) and CRV + VRC (60%). Our findings suggest that CRV and THY have potent activity when combined with CAS, AMB or VRC.