Anti-leukemia activities of selenium nanoparticles embedded in nanotube consisted of triple-helix β-d-glucan. (15th July 2020)

• Record Type: Journal Article
• Authors: Jin, Yanxia; Cai, Liqin; Yang, Qian; Luo, Ziyi; Liang, Li; Liang, Yuxing; Wu, Balu; Ding, Lu; Zhang, Dongdong; Xu, Xiaojuan; Zhang, Lina; Zhou, Fuling
• Is Part Of: Carbohydrate polymers. Volume 240(2020)
• Publication Date: 2020-07-15
• Subjects: AML acute myeloid leukemia -- PBMCs peripheral blood mononuclear cells -- HLL hyperleukocytic leukemia -- LDH lactate dehydrogenase -- HSCs hematopoietic stem cells -- Ara-c cytosine arabinoside -- T-AOC total antioxidant capacity -- GSH glutathione -- XOD xanthine oxidase -- Jab1 c-Jun activation domain-binding protein l -- Trx1 thioredoxin 1 -- PDX patient-derived xenograft; Triple helix glucan -- Se nanoparticles -- Acute myeloid leukemia -- Cytotoxicity -- PDX model; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.116329
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: BFP-Se was self-assembled and exhibited high stability in water. BFP-Se significantly exerted the anti-leukemia effects in vitro and in vivo. BFP-Se decreased the expression of Jab1 and Trx1 in AML cells. Abstract: Acute myeloid leukemia (AML) is a difficult therapeutic hematological tumor. It is urgent to find a non-toxic natural drug to treat AML. Herein, the selenium nanoparticles (SeNPs) embedded in nanotubes consisted of triple helix β-(1, 3)-d -glucan (BFP) from the black fungus that were wrapped to form stable inclusion complex BFP-Se, which was self-assembled and exhibited high stability in water. In vitro, the BFP-Se significantly inhibited the proliferation of AML cells and increased the cytotoxicity on AML cells. On single-cell levels, the U937 cells were gradually swelled and lysed with BFP-Se treatment on optofluidics chips. Further, the blood and bone marrow analysis indicated the anti-leukemia effects of BFP-Se in vivo. Moreover, BFP-Se increased the total antioxidant capacity of AML cells and decreased the expression of c-Jun activation domain-binding protein 1 and thioredoxin 1. Our results suggest that this biocompatible polysaccharide nanotube containing Se nanoparticles would provide a novel strategy for AML therapy.