Zataria multiflora and its main ingredient, carvacrol, affect on the renal function, histopathological, biochemical and antioxidant parameters in adriamycin-induced nephrotic rats. (3rd September 2021)

• Record Type: Journal Article
• Authors: Mohebbati, Reza; Jalili-Nik, Mohammad; Saghi, Hossein; Sadatfaraji, Hamed; Soukhtanloo, Mohammad
• Is Part Of: Archives of physiology and biochemistry. Volume 127:Number 5(2021)
• Page Start: 453
• Page End: 461
• Publication Date: 2021-09-03
• Subjects: Adriamycin -- Zataria multiflora -- carvacrol -- nephrotic syndrome -- oxidative stress; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2019.1650069
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Oxidative stress has a major role in the nephrosis. In the present study, the effects of hydroalcoholic extract of Zataria multiflora (ZM) and carvacrol (CAR) were evaluated on the renal damage induced by adriamycin (ADR). The animals accidentally divided into four groups including: Control, ADR, ZM + ADR and CAR + ADR. The renal tissue, urine, and blood samples subjected to biochemical markers and histopathological evaluation. ADR significantly decreased glomerular filtration rate (GFR) while escalated urine protein excretion as well as protein clearance ( p < .01 to p < .001). Also, ADR significantly reduced the antioxidants and boosted the malondialdehyde (MDA) compared to the control ( p < .05 to p < .01). In groups treated by ZM and CAR, GFR, and antioxidants significantly increased, whereas urine protein excretion and MDA decreased ( p < .05 to p < .001). ZM and CAR induced an improvement in ADR-induced renal damage by improving renal function as well as antioxidant activity.