Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1. (4th July 2021)

• Record Type: Journal Article
• Authors: Raia, Pierre; Yu, Jun; Boland, Andreas
• Is Part Of: Molecular & cellular oncology. Volume 8:Number 4(2021)
• Publication Date: 2021-07-04
• Subjects: Cell cycle -- cohesin -- autoinhibition -- substrate occlusion -- caspase -- oncogene -- mitosis; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2021.1975473
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Accurate chromosome segregation depends on tight regulation of the protease separase, which cleaves the ring-shaped cohesin complex that entraps the two sister chromatids. We recently reported structures of human separase bound to its inhibitors securin or the cyclin-dependent kinase 1 (CDK1)-cyclin B1 (CCNB1)-cyclin-dependent kinases regulatory subunit 1 (CKS1) complex and discovered an array of molecular mechanisms that block cohesin-cleavage.