A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer. (4th July 2021)

• Record Type: Journal Article
• Authors: Rodgers, Samuel J.; Hamila, Sabryn A.; Mitchell, Christina A.; Ooms, Lisa M.
• Is Part Of: Molecular & cellular oncology. Volume 8:Number 4(2021)
• Publication Date: 2021-07-04
• Subjects: INPP4B -- PIK3CA -- WNT/β-catenin -- late endosome -- cell proliferation; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2021.1954470
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER + ) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly characterized. We discovered that a subset of PIK3CA -mutant ER + breast cancers exhibit increased inositol polyphosphate 4-phosphatase type II (INPP4B) expression, which promotes late endosome formation and glycogen synthase kinase 3 beta (GSK3β) trafficking, leading to enhanced Wingless–related integration site (WNT)/catenin beta 1 (β-catenin) activation.