Are HLA antigens important in the development of alcohol-induced liver disease?. Issue 6341 (21st August 1982)

• Record Type: Journal Article
• Authors: Faizallah, R; Woodrow, J C; Krasner, N K; Walker, R J; Morris, A I
• Is Part Of: BMJ. Volume 285:Issue 6341(1982)
• Page Start: 533
• Page End: 534
• Publication Date: 1982-08-21
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.285.6341.533
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : The prevalences of 10 HLA-A and 16 HLA-B antigens were determined in 50 patients with alcoholic cirrhosis and 120 alcoholic patients without cirrhosis and compared with those in a control group of 550 healthy subjects from the same geographical area. B40 was absent in the patients with cirrhosis but was found in 18 (15%) of the patients without cirrhosis (p = 0.0087). No other association was noted. It is concluded that there is no good evidence to date of an association between HLA antigen state and susceptibility to alcohol-induced cirrhosis.