Curcumin immobilized metal organic framework based fluorescent nanoprobe for selective sensing and bioimaging of Fe(II). (September 2021)

• Record Type: Journal Article
• Authors: Kumar, Yogesh; Kaushik, Rahul; Rani, Swati; Rafat, Sahar; Shabir, Javaid; Dev, Kapil; Kumar, Lalita S.
• Is Part Of: Materials today communications. Volume 28(2021)
• Publication Date: 2021-09
• Subjects: MOF -- ZIF-8 -- Curcumin -- Fluorescent sensor -- Cell imaging -- Iron sensor; Materials science -- Periodicals; 620.11
• DOI: 10.1016/j.mtcomm.2021.102563
• Languages: English
• ISSNs: 2352-4928

Abstract

Abstract: Curcumin immobilized zeolitic imidazolate framework-8 (Cmim@ZIF-8) based probe has been reported in order to detect Fe(II) ions in aqueous medium. The Cmim@ZIF-8 nanoprobe was synthesized by a one pot process and characterized by various techniques such as X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscope and Brunauer−Emmett−Teller surface area measurement. The prepared material (Cmim@ZIF-8) was tested against various monovalent and divalent metal ions and found to be selective for detection of Fe(II). Cmim@ZIF-8 exhibit turn off fluorescence intensity with Fe(II) ions due to displacement of Curcumin indicator from ZIF-8 surface with a detection limit of 7.64 μM. Furthermore, Cmim@ZIF-8 was successfully utilised to detect Fe(II) in live HepG2 cells through fluorescence confocal imaging. Graphical Abstract: ga1