A multi-institutional outbreak of New Delhi metallo-β-lactamase–producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene. (29th September 2021)

• Record Type: Journal Article
• Authors: Solter, Ester; Kwong, Jason C.; Walton, Aaron; Sherry, Norelle; Howden, Benjamin P.; Grayson, M. Lindsay; Schwartz, David; Temkin, Elizabeth; Frenk, Sammy; Carmeli, Yehuda; Schwaber, Mitchell J.
• Is Part Of: Infection control and hospital epidemiology. Volume 42:Number 9(2021)
• Page Start: 1124
• Page End: 1127
• Publication Date: 2021-09-29
• Subjects: Nosocomial infections -- Epidemiology -- Periodicals; Health facilities -- Sanitation -- Periodicals; Hospital buildings -- Sanitation -- Periodicals; Cross Infection -- Periodicals; Epidemiology -- Periodicals; Hospitals -- Periodicals; Infection Control -- Periodicals; 614.44
• DOI: 10.1017/ice.2020.1361
• Languages: English
• ISSNs: 0899-823X

Abstract

Abstract: We characterized 57 isolates from a 2-phase clonal outbreak of New Delhi metallo-β-lactamase–producing Eschericha coli, involving 9 Israeli hospitals; all but 1 isolate belonged to sequence-type (ST) 410. Most isolates in the second phase harbored bla KPC-2 in addition to bla NDM-5 . Genetic sequencing revealed most dual-carbapenemase–producing isolates to be monophyletically derived from a common ancestor.