Modeling of Deformable Cell Separation in a Microchannel with Sequenced Pillars (Adv. Theory Simul. 9/2021). Issue 9 (7th September 2021)

• Record Type: Journal Article
• Authors: Hymel, Scott J.; Fujioka, Hideki; Khismatullin, Damir B.
• Is Part Of: Advanced theory and simulations. Volume 4:Issue 9(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-07
• Subjects: Science -- Simulation methods -- Periodicals; Science -- Methodology -- Periodicals; Engineering -- Simulation methods -- Periodicals; Engineering -- Methodology -- Periodicals; 507.21
• DOI: 10.1002/adts.202170020
• Languages: English
• ISSNs: 2513-0390

Abstract

Abstract : Modeling Cell Separation in a Microchannel In article number 2100086, Damir Khismatullin and co‐workers identify multi‐pillar configurations that can increase the efficiency of microfluidic separation of deformable cells by ≈1300% using numerical algorithms for cell migration. Separation of circulating tumor cells (red) and white blood cells (blue) in a microfluidic channel with three widely spaced columns is shown. The pillars disrupt the velocity field (inlet), altering the direction of the cells and increasing the cell‐to‐cell distance.