Metabolic effects of salbutamol: comparison of aerosol and intravenous administration. Issue 6058 (12th February 1977)

• Record Type: Journal Article
• Authors: Neville, A; Palmer, J B; Gaddie, J; May, C S; Palmer, K N; Murchison, L E
• Is Part Of: BMJ. Volume 1:Issue 6058(1977)
• Page Start: 413
• Page End: 414
• Publication Date: 1977-02-12
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.1.6058.413
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : The effects of intravenous salbutamol (4 mug/kg) were compared with those of aerosol salbutamol (200 mug) in 10 asthmatic patients in a double-blind placebo-controlled study. Both methods of administration produced equal bronchodilatation. Intravenous salbutamol caused significant increases in plasma insulin and glucose levels and a fall in serum potassium concentration in addition to tachycardia and tremor, whereas aerosol salbutamol produced only a small transient increase in the plasma glucose level. The initially raised non-esterified fatty acid levels decreased significantly after aerosol and placebo but not after intravenous salbutamol.