17 Postpartum lupus encephalopathy in a patient with systemic lupus erythematosus complicated with antiphospholipid antibody syndrome. (March 2019)

• Record Type: Journal Article
• Authors: Liu, EL; Liu, Z; Zhou, YX
• Is Part Of: Journal of investigative medicine. Volume 67(2019)Supplement 1
• Page Start: A5
• Page End: A6
• Publication Date: 2019-03
• Subjects: Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.1136/jim-2019-000994.17
• Languages: English
• ISSNs: 1081-5589

Abstract

Abstract : Background: SLE complicated with antiphospholipid syndrome (APS) is very rare during pregnancy. Both SLE and APS can be associated with pregnancy failure, fetal loss and obstetric complications. Methods: We report on a 21-year-old female diagnosed with SLE, APS, and postpartum lupus encephalopathy and review the literature at home and abroad. Results: In this case, Acl IgA/G/M and ANA were positive. The patient with SLE combined with APS had premature rupture of the membrane for 28+3 weeks. The patient's condition was stable during 1 month of fetal treatment and the child was delivered live. She had a headache and blurred vision after caesarean section. Following the related auxiliary examination, the patient was diagnosed with lupus encephalopathy (activity). After immediate high-dose hormone pulse therapy, the patient's condition gradually recovered and the hormone gradually reduced. Until discharged, the patient had no other discomfort but her vision was 1.5 meters index. Two months after discharge, the general condition of the patient is better, the symptoms of encephalopathy have disappeared and her vision is largely restored. Conclusion: SLE patients with APS have a high-risk of pregnancy-related complications. Timely and clear diagnosis and positive and appropriate treatment can improve the prognosis of mother and infant, and reduce the incidence of complications. Acknowledgements: Supported by a key project grant from He Bei Department of Science and Technology (Grand No.162777190).