Wireless, Skin‐Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring. Issue 17 (3rd May 2021)

• Record Type: Journal Article
• Authors: Liu, Claire; Kim, Jin‐Tae; Kwak, Sung Soo; Hourlier‐Fargette, Aurelie; Avila, Raudel; Vogl, Jamie; Tzavelis, Andreas; Chung, Ha Uk; Lee, Jong Yoon; Kim, Dong Hyun; Ryu, Dennis; Fields, Kelsey B.; Ciatti, Joanna L.; Li, Shupeng; Irie, Masahiro; Bradley, Allison; Shukla, Avani; Chavez, Jairo; Dunne, Emma C.; Kim, Seung Sik; Kim, Jungwoo; Park, Jun Bin; Jo, Han Heul; Kim, Joohee; Johnson, Michael C.; Kwak, Jean Won; Madhvapathy, Surabhi R.; Xu, Shuai; Rand, Casey M.; Marsillio, Lauren E.; Hong, Sue J.; Huang, Yonggang; Weese‐Mayer, Debra E.; Rogers, John A.;
• Other Names: Gao Wei guestEditor.; Yu Cunjiang guestEditor.
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 17(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-03
• Subjects: blood pressure -- hemodynamics -- pediatrics -- soft electronics -- vital signs monitoring -- wireless wearables; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202100383
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Indwelling arterial lines, the clinical gold standard for continuous blood pressure (BP) monitoring in the pediatric intensive care unit (PICU), have significant drawbacks due to their invasive nature, ischemic risk, and impediment to natural body movement. A noninvasive, wireless, and accurate alternative would greatly improve the quality of patient care. Recently introduced classes of wireless, skin‐interfaced devices offer capabilities in continuous, precise monitoring of physiologic waveforms and vital signs in pediatric and neonatal patients, but have not yet been employed for continuous tracking of systolic and diastolic BP—critical for guiding clinical decision‐making in the PICU. The results presented here focus on materials and mechanics that optimize the system‐level properties of these devices to enhance their reliable use in this context, achieving full compatibility with the range of body sizes, skin types, and sterilization schemes typically encountered in the PICU. Systematic analysis of the data from these devices on 23 pediatric patients, yields derived, noninvasive BP values that can be quantitatively validated against direct recordings from arterial lines. The results from this diverse cohort, including those under pharmacological protocols, suggest that wireless, skin‐interfaced devices can, in certain circumstances of practical utility, accurately and continuously monitor BP in the PICU patient population. Abstract : Wireless, skin‐interfaced devices, with optimized system‐level mechanics and soft materials tailored to the pediatric intensive care unit environment, offer a route for continuous, noninvasive blood pressure (BP) monitoring via measurements of pulse arrival time and heart rate. These devices continuously track short‐ and long‐term BP trends, including during periods of pharmacological interventions.