BamH I polymorphism in the Chinese: its potential usefulness in prenatal diagnosis of beta thalassaemia. Issue 6450 (13th October 1984)

• Record Type: Journal Article
• Authors: Chan, V; Leung, N K; Chan, T K; Ghosh, A; Kan, Y W; Todd, D
• Is Part Of: BMJ. Volume 289:Issue 6450(1984)
• Page Start: 947
• Page End: 948
• Publication Date: 1984-10-13
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.289.6450.947
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : The prevalence of the BamH I site 3' to the beta globin gene in Chinese people was determined in 123 normal subjects, 40 patients with heterozygous beta thalassaemia, and 25 patients with homozygous beta thalassaemia. The site was present in 71.1% and absent in 28.9% of the chromosomes carrying normal beta genes. All 25 patients with beta thalassaemia major had the site. This BamH I polymorphism may be used for prenatal diagnosis in about 29% of the pregnancies at risk.