Reduced severity of Rh-haemolytic disease after anti-D immunoglobulin. Issue 5992 (8th November 1975)

• Record Type: Journal Article
• Authors: Derrick Tovey, L A; Robinson, A E
• Is Part Of: BMJ. Volume 4:Issue 5992(1975)
• Page Start: 320
• Page End: 322
• Publication Date: 1975-11-08
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.4.5992.320
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : A total of 2459 Rh-negative women who received anti-D immunoglobulin after a Rh-positive pregnancy were followed up in at least one subsequent pregnancy. There was a failure of protection rate of 1-6%. Follow-up of 53 subsequent infants of mother in whom protection had failed showed that the infants were less severely affected than would have been expected. This was confirmed by a comparative statistical analysis of the present series and a series of first affected cases before anti-D immunoglobulin was available, using the antibody titre during pregnancy and the haemoglobin levels at delivery.