Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes. Issue 6087 (3rd September 1977)

• Record Type: Journal Article
• Authors: Fox, C J; Darby, S C; Ireland, J T; Sönksen, P H
• Is Part Of: BMJ. Volume 2:Issue 6087(1977)
• Page Start: 605
• Page End: 607
• Publication Date: 1977-09-03
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.2.6087.605
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Glomerular capillary basement membrane thickness (BMT) was measured in 23 rats which had had streptozocin-induced diabetes for 14 months and in 12 age-matched controls. Diabetic rats were randomly allocated to different groups, either receiving no treatment or treated with a low carbohydrate diet or insulin, or both. Control rats were randomly allocated to a normal or low carbohydrate diet. Among the diabetic rats mean plasma glucose concentrations for the groups ranged from 27-4 mmol/l (494 mg/100 ml) in the untreated rats to 9-8 mmol/l (177 mg/100 ml) in those receiving both a low carbohydrate diet and insulin. A highly significant positive relation was found between BMT and plasma glucose concentration for individual rats. When BMT was corrected for body weight a similar relation was observed.