IDDF2020-ABS-0181 Disease burden, risk factors, and recent trends of colorectal cancer: a global analysis of data from 186 countries. (18th November 2020)

• Record Type: Journal Article
• Authors: Huang, Junjie; Patel, Harsh K; Lucero-Prisno, Don Eliseo; Boakye, Daniel; Chandrasekar, Viveksandeep Thoguluva; Lok, Veeleah; Liu, Xianjing; Zhang, Lin; Yuan, Jinqiu; Lao, Xiang-Qian; Tse, Shelly LA; Xu, Wanghong; Zheng, Zhi-Jie; Wong, Martin CS
• Is Part Of: Gut. Volume 69(2020)Supplement 2
• Page Start: A5
• Page End: A5
• Publication Date: 2020-11-18
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gutjnl-2020-IDDF.8
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Background: This study aimed to evaluate the updated incidence, mortality, risk factors, and epidemiologic trends of colorectal cancer (CRC) for different regions and sex using publicly available data from 186 countries. Methods: The Global Cancer Observatory ( GLOBOCAN ) database was retrieved for the age-standardized rates (ASR) for incidence and mortality of CRC in 2018 and 2012. The prevalence of risk factors (2008–2016) was retrieved from the Global Health Observatory database. The associations between the prevalence of risk factors and incidence and mortality of CRC and were measured using beta coefficients ( β ) with 95% confidence intervals (CI) generated from a univariable linear regression analysis. Results: In 2018, the highest incidence and mortality of CRC were in regions of very high human development index (HDI) (ASRs, 30.6 and 11.1) with men to women ratio of 1.4 and 1.2. Population in countries with higher incidence have higher alcohol consumption ( β =1.30, 95% CI 1.02 to 1.57 for men; β =0.46, CI 0.35 to 0.57 for women), higher prevalence of tobacco use ( β =0.11, CI 0.02 to 0.19 for women), insufficient physical activity ( β =0.59, CI 0.34 to 0.84; β =0.19, CI 0.09 to 0.29), overweight ( β =0.47, CI 0.38 to 0.57; β =0.16, CI 0.12 to 0.20), obesity ( β =0.24, CI 0.11 to 0.38; β =0.34, CI 0.25 to 0.43), and elevated cholesterol ( β =1.80, CI 1.53 to 2.07; β =1.22, CI 1.05 to 1.38). Similar associations were also found for mortality (figure 1 ). From 2012 to 2018, there was an overall increase in the trend of incidence and mortality, particularly in Asia (+29.7% and +17.4%) and Africa (+24.3% and +17.6%), and among men (+14.6% and +8.0%) compared with women (+14.0% and +4.3%). Conclusions: The variation in disease burden of CRC was associated with HDI and the prevalence of risk factors. There was an increasing trend in the incidence and mortality of CRC, particularly in regions with low and middle incomes and among men. More intensive lifestyle modifications and population-based screening are recommended for these populations.