Clinical Evaluation of Perhexiline Maleate in Patients with Angina Pectoris. Issue 5787 (4th December 1971)

• Record Type: Journal Article
• Authors: Burns-Cox, C. J.; Chandrasekhar, K. P.; Ikram, H.; Peirce, T. H.; Pilcher, J.; Quinlan, C. D. M.; Rees, J. Russell
• Is Part Of: BMJ. Volume 4:Issue 5787(1971)
• Page Start: 586
• Page End: 588
• Publication Date: 1971-12-04
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.4.5787.586
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : This paper reports a double-blind trial of a new antianginal drug, perhexiline. Fifty-five patients suffering from angina pectoris were studied for periods of 12 or 24 weeks in a cross-over comparison against a placebo in four centres in the United Kingdom and Ireland. Perhexiline was effective in most patients as judged by reducing the number of anginal attacks in 84% and the consumption of glyceryl trinitrate tablets in 64%. The major side effect, dizziness, noted in one-third of the patients, may be dose/body-weight related. Perhexiline is a valuable new agent for the treatment of patients with angina, especially those who do not respond to other antianginal agents.