H-rosette formation in T-cell-proliferative diseases. Issue 5993 (15th November 1975)

• Record Type: Journal Article
• Authors: Sheldon, P J; Holborow, E J
• Is Part Of: BMJ. Volume 4:Issue 5993(1975)
• Page Start: 381
• Page End: 383
• Publication Date: 1975-11-15
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.4.5993.381
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : In health up to 6% of human lymphocytes will form rosettes with homologous group O rhesus-negative erythrocytes (H rosettes). Increased numbers of H rosettes were found in T-cell-proliferative diseases-- namely, infectious mononucleosis, Sézary's syndrome, and T-cell leukaemia. H-rosette formation is thus a marker for a subpopulation of T lymphocytes, and this easily performed test of T-cell activation may have clinical value in characterising changes in blood lymphocyte populations in disease.