Anti-inflammatory quinolizidine alkaloids from the aerial parts of Sophora tonkinensis. (October 2021)

• Record Type: Journal Article
• Authors: Zhang, Yuan-Ya; Liu, Dan; Ye, Rui-Rong; Chen, Xuan-Qin; Li, Rong-Tao; Zhang, Zhi-Jun
• Is Part Of: Phytochemistry letters. Volume 45(2021)
• Page Start: 121
• Page End: 125
• Publication Date: 2021-10
• Subjects: Sophora tonkinensis -- Quinolizidine alkaloids -- Matrine -- Sophoranol -- Anti-inflammatory; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2021.08.010
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Seventeen alkaloids were isolated from the aerial parts of Sophora tonkinensis. All isolates were evaluated for their inhibitory effects on the NO production in LPS-induced RAW 264.7 macrophages. Compounds 3, 4, 13, and 14 were shown to have moderate anti-inflammatory effects. Abstract: Seventeen quinolizidine alkaloids, including two new ones, 5-hydoxy-7, 11-dehydromatrine (1 ) and 11-hydroxylupanine (2 ), were isolated from the aerial parts of Sophora tonkinensis. The structures of the isolates were elucidated using 1D and 2D NMR analyses, as well as HR-ESI-MS spectroscopic data. The anti-inflammatory activities of all the isolates on NO production in RAW 264.7 cells stimulated by lipopolysaccharide (LPS) were evaluated. Compounds 3, 4, 13, and 14 were shown to have moderate anti-inflammatory effects.