A concise review towards defining the exposome of oesophageal cancer in sub-Saharan Africa. (December 2021)

• Record Type: Journal Article
• Authors: Lipenga, Trancizeo; Matumba, Limbikani; Vidal, Arnau; Herceg, Zdenko; McCormack, Valerie; De Saeger, Sarah; De Boevre, Marthe
• Is Part Of: Environment international. Volume 157(2021)
• Publication Date: 2021-12
• Subjects: Oesophageal cancer -- Oesophageal squamous cell carcinoma -- Exposome -- Africa -- Environmental health; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2021.106880
• Languages: English
• ISSNs: 0160-4120

Abstract

Highlights: ESCC has a poor prognosis, especially in low-income settings. The aetiology of ESCC remains incompletely understood in SSA. Available evidence suggests a multifactorial contribution of ESCC exposures. Integration of epidemiology and exposome data may help unravel ESCC aetiology. Abstract: Context: Oesophageal cancer (EC) is among the common causes of illness and death among all cancers worldwide. Advanced EC has a poor prognosis, with worse outcomes observed in low-income settings. Oesophageal squamous cell carcinoma (ESCC) is the most common EC histology reported globally, with the highest ESCC incidence rates in the 'Asian Belt' and the African EC corridor. While the aetiology of ESCC is well-documented in the 'Asian belt', data for the African EC corridor and the entirety of sub-Saharan Africa (SSA) are fewer. Objective: To help address gaps in ESCC aetiology in SSA, we critically evaluated evidence of lifestyle, environmental, and epigenetic factors associated with ESCC risk and discussed prospects of defining ESCC exposome. Data inclusion: Unlimited English and non-English articles search were made on PubMed Central and Web of Science databases from January 1970 to August 2021. In total, we retrieved 999 articles and considered meta -analyses, case-control, and cohort studies. The quality of individual studies was assessed using the Newcastle–Ottawa scale. Data extraction: Details extracted include the year of publication, country of origin, sample size, comparators, outcomes, study subjects, and designs. Data analysis: Together, we assessed 13 case-control studies and two meta -analyses for the effect of lifestyle or environmental exposures on ESCC risk. Again, we evaluated seven case-control studies and one meta -analysis regarding the role of epigenetics in ESCC tumorigenesis. Results: In general, evidence of ESCC aetiology points to essential contributions of alcohol, tobacco, hot beverages, biomass fuel, and poor oral health/hygiene, although more precise risk characterisation remains necessary. Conclusion: We conclude that ESCC in SSA is a multifactorial disease initiated by several external exposures that may induce aberrant epigenetic changes. The expanding aetiological research in this domain will be enhanced by evidence synthesis from classical and molecular epidemiological studies spanning the external and internal exposome.