A new phenylethyl glycoside and a new dibenzocyclooctadiene lignan from the leaves of Kadsura coccinea (Lem.) A. C. Smith. (October 2021)

• Record Type: Journal Article
• Authors: Le, Huyen Tram; Tran, Thu Huong; Le, Thi Thuy; Nguyen, Van Thong; Nguyen, Tuan Anh; Nguyen, Hoang Minh; Tran, Thi Minh; Nguyen, Thi Hong Phuong; Tran, Thu Ha; Nguyen, Hai Dang; Le, Duc Dat; Pham, Phuoc Dien; Lee, Mina
• Is Part Of: Phytochemistry letters. Volume 45(2021)
• Page Start: 57
• Page End: 62
• Publication Date: 2021-10
• Subjects: Kadsura coccinea -- Phenolic compound -- Dibenzocyclooctadiene lignan -- NO inhibition; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2021.07.012
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Two new and seven known compounds were isolated from K. coccinea (Lem.) A. C. Smith leaves. Chemical structures were established by spectroscopic, MS data, or analytical HPLC experiment. Isolates were evaluated for their inhibition of NO production in LPS-induced RAW264.7 cells. Abstract: A new phenylethyl glycoside (1 ), ( S )-1-phenylethyl-6- α -L-arabinopyranosyl- β -D-glucopyranoside), and a new dibenzocyclooctadiene lignan (7 ), Kasuracin A, together with seven known compounds, were isolated and identified from the leaves of Kadsura coccinea . Their structures were determined by analysis of multinuclear and multidimensional nuclear magnetic resonance (NMR), circular dichroism (CD), mass spectrometry, hydrolysis analysis, or comparison to those reported in the literature. Then, all the isolates 1 ‒9 were evaluated for their inhibitory effects against nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Among them, compounds 2 and 3 were isolated for the first time from this plant and compounds 3, 7, 8, and 9 significantly inhibited NO production with IC50 values of 36.4, 10.2, 12.3, and 21.7 μM, respectively.