Sesquiterpenes and lipids from the algicolous fungus Trichoderma atroviride RR-dl-3-9. (October 2021)

• Record Type: Journal Article
• Authors: Liu, Xiang-Hong; Song, Yin-Ping; Wang, Bin-Gui; Ji, Nai-Yun
• Is Part Of: Phytochemistry letters. Volume 45(2021)
• Page Start: 6
• Page End: 12
• Publication Date: 2021-10
• Subjects: Trichoderma atroviride -- Hypocreaceae -- Terpene -- Steroid -- Lauric acid; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2021.07.003
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Metabolites of the algicolous Trichoderma atroviride are reported for the first time. Trichobisabolins M and N are the first bisabolane derivatives from Trichoderma atroviride . Two lauric acid derivatives feature antibacterial activities. Abstract: Two new bisabolane derivatives, trichobisabolins M (1 ) and N (2 ), one new steroid derivative, 4-(p-hydroxyphenethoxy)demethylincisterol A3 (3 ), and one new lauric acid derivative, methyl 3, 5-dihydroxydodecanoate (4 ), as well as (3 R, 5 R )-3-hydroxy-5-dodecanolide (5 ) were isolated from the marine-alga-endophytic Trichoderma atroviride RR-dl-3−9. Their structures and relative configurations were assigned mainly by NMR and mass spectroscopic techniques, and their absolute configurations were confirmed on the basis of specific optical rotation, ECD, and X-ray crystallographic data. Compounds 1 and 2 represent the first occurrence of bisabolane derivatives from this species. The five isolates were assayed for inhibiting four marine phytoplankton and five marine-derived bacteria, and the two lauric acid derivatives showed antibacterial activities with MIC values ranging from 13 to 50 μg/mL.