Chemically and Biologically Engineered Bacteria‐Based Delivery Systems for Emerging Diagnosis and Advanced Therapy. Issue 38 (4th August 2021)

• Record Type: Journal Article
• Authors: Li, Zhaoting; Wang, Yixin; Liu, Jun; Rawding, Piper; Bu, Jiyoon; Hong, Seungpyo; Hu, Quanyin
• Is Part Of: Advanced materials. Volume 33:Issue 38(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-08-04
• Subjects: bacteria -- bioengineering -- chemical engineering -- diagnosis -- therapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202102580
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Bacteria are one of the main groups of organisms, which dynamically and closely participate in human health and disease development. With the integration of chemical biotechnology, bacteria have been utilized as an emerging delivery system for various biomedical applications. Given the unique features of bacteria such as their intrinsic biocompatibility and motility, bacteria‐based delivery systems have drawn wide interest in the diagnosis and treatment of various diseases, including cancer, infectious diseases, kidney failure, and hyperammonemia. Notably, at the interface of chemical biotechnology and bacteria, many research opportunities have been initiated, opening a promising frontier in biomedical application. Herein, the current synergy of chemical biotechnology and bacteria, the design principles for bacteria‐based delivery systems, the microbial modulation, and the clinical translation are reviewed, with a special focus on the emerging advances in diagnosis and therapy. Abstract : Bacteria‐based delivery systems are versatile platforms developed for diagnosis and therapy. The fundamentals and design principles of chemically and biologically engineered bacteria delivery systems are summarized, and recent advances of their application in emerging diagnosis and advanced therapy are highlighted, including microbial modulation and clinical translation, which have offered tremendous promise for various disease treatments.