Tumefactive demyelination in pediatrics: An unusual late neurological complication of hematopoietic stem cell transplant. Issue 11 (1st September 2021)

• Record Type: Journal Article
• Authors: Haldorai, Meena; Kamila, Gautam; Gupta, Aditya Kumar; Meena, Jagdish Prasad; Jauhari, Prashant; Jana, Manisha; Kumar, Atin; Brijwal, Megha; Chakrabarty, Biswaroop; Gulati, Sheffali; Seth, Rachna
• Is Part Of: Pediatric blood & cancer. Volume 68:Issue 11(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-01
• Subjects: allogeneic HSCT -- immune‐mediated demyelination -- tumefactive demyelination; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.29318
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Immune‐mediated demyelination is a rare posttransplant complication. Here, we report an 8.5‐year‐old boy who developed left hemiparesis, 18 months post matched sibling donor hematopoietic stem cell transplant (HSCT) for relapsed acute myeloid leukemia and was diagnosed to have tumefactive demyelination. The diagnosis was established based on clinical and radiological features. The complete resolution of the lesions with steroids further established the immune‐mediated pathophysiology.