2‐Deoxy‐d‐glucose exploits increased glucose metabolism in cancer and viral‐infected cells: Relevance to its use in India against SARS‐CoV‐2. Issue 10 (2nd September 2021)

• Record Type: Journal Article
• Authors: Mesri, Enrique A.; Lampidis, Theodore J.
• Is Part Of: IUBMB life. Volume 73:Issue 10(2021)
• Page Start: 1198
• Page End: 1204
• Publication Date: 2021-09-02
• Subjects: 2‐deoxy‐d‐glucose or 2‐DG -- cancer -- cellular glucose metabolism -- ER stress -- glycolysis -- SARS‐CoV‐2 -- viruses; Biochemistry -- Periodicals; Molecular biology -- Periodicals; 572.8
• DOI: 10.1002/iub.2546
• Languages: English
• ISSNs: 1521-6543

Abstract

Abstract: Mechanisms discovered to drive increased glucose metabolism in cancer cells are found to be similar to those in viral‐infected cells. In this mini review, we summarize the major pathways by which the sugar analog, 2‐Deoxy‐d ‐glucose, has been shown to exploit increased glucose metabolism in cancer and how this information applies to viral‐infected cells. Moreover, we highlight the relevance of these findings to the emergency approval of 2‐Deoxy‐d ‐glucose in India to be used against SARS‐CoV‐2, the virus responsible for COVID‐19.