Post‐ESWL and post‐ERCP pancreatitis in patients with chronic pancreatitis: Do they share the same risks?. (22nd July 2021)

• Record Type: Journal Article
• Authors: Ru, Nan; Qian, Yang‐Yang; Zhu, Jia‐Hui; Chen, Hui; Zou, Wen‐Bin; Hu, Liang‐Hao; Pan, Jun; Guo, Ji‐Yao; Li, Zhao‐Shen; Liao, Zhuan
• Is Part Of: Journal of hepato-biliary-pancreatic sciences. Volume 28:Number 9(2021)
• Page Start: 778
• Page End: 787
• Publication Date: 2021-07-22
• Subjects: calculi -- chronic pancreatitis -- endoscopic retrograde cholangiopancreatography -- extracorporeal shockwave lithotripsy -- risk factors; Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 617.556
• DOI: 10.1002/jhbp.1013
• Languages: English
• ISSNs: 1868-6974

Abstract

Abstract: Background: Endoscopic intervention combined with extracorporeal shock wave lithotripsy (ESWL) is recommended as the first line therapy for large pancreatic stones, yet both can cause adverse events. The aim of the study was to identify the risk factors for post‐procedural pancreatitis. Methods: Consecutive patients with chronic pancreatitis and pancreatic stones treated with both ESWL and subsequent endoscopic retrograde cholangiopancreatography (ERCP) from October 2016 to December 2019 were prospectively enrolled. Multivariate logistic analyses were performed to detect risk factors for post‐ESWL and post‐ERCP pancreatitis (PEP). Results: A total of 714 patients (507 males, 45.60 ± 12.52 years) were included in this study. A total of 80 patients (11.2%) developed post‐ESWL pancreatitis, while 33 patients (4.6%) suffered from PEP. Steatorrhea ( P = .018), multiple stones ( P = .043), and stones located at the head combined with the body or tail of the pancreas ( P = .015) were identified as independent protective factors for post‐ESWL pancreatitis. The history of acute exacerbations ( P = .013), post‐ESWL pancreatitis ( P < .001) and stricture dilation during ERCP ( P = .002) were identified as risk factors for PEP. Conclusions: More attention should be paid to patients with post‐ESWL pancreatitis, as well as a history of acute exacerbations and stricture dilation during ERCP to prevent PEP. (ClincialTrials.gov number, NCT04619511). Abstract : Highlight Ru and colleagues conducted an observational study to investigate the risk factors for and relationship between post‐ESWL and post‐ERCP pancreatitis in patients with chronic pancreatitis. The incidence of post‐ESWL pancreatitis showed a significant downward trend over successive ESWL sessions. Post‐ESWL pancreatitis was identified as a risk factor for post‐ERCP pancreatitis.