Retrospective study of peptide receptor radionuclide therapy for Japanese patients with advanced neuroendocrine tumors. (14th July 2021)

• Record Type: Journal Article
• Authors: Kobayashi, Noritoshi; Wild, Damian; Kaul, Felix; Shimamura, Takeshi; Takano, Shoko; Takeda, Yuma; Okubo, Naoki; Suzuki, Akihiro; Tokuhisa, Motohiko; Ichikawa, Yasushi
• Is Part Of: Journal of hepato-biliary-pancreatic sciences. Volume 28:Number 9(2021)
• Page Start: 727
• Page End: 739
• Publication Date: 2021-07-14
• Subjects: neuroendocrine tumor -- peptide receptor radionuclide therapy -- somatostatin receptor scintigraphy; Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 617.556
• DOI: 10.1002/jhbp.1014
• Languages: English
• ISSNs: 1868-6974

Abstract

Abstract: Background: Peptide receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogs is an innovative treatment for advanced somatostatin‐positive neuroendocrine tumors (NETs). PRRT cannot be performed in Japan because there is no approval or insurance cover so far. Methods: We relied on foreign institutions to perform PRRT for Japanese patients with NETs. We retrospectively evaluated the safety and efficacy of PRRT. The inclusion criteria were pathologically confirmed well‐differentiated NET and visible tumor uptake on pre‐therapeutic somatostatin receptor scintigraphy. 177 Lu‐DOTA‐TOC was used as the standard treatment, and patients received three infusions every 8 weeks. Until the end of 2017, combination treatment with 90 Y and 177 Lu‐DOTA‐TOC was performed using the same protocol. Results: Thirty‐five patients were evaluated, and the primary lesions were pancreas, rectum, small intestine, stomach, and other locations. The partial response rate was 42.9%. Progression‐free survival (PFS) was 12.8 months and overall survival was 42.8 months. There was no significant difference in PFS between front‐line and late‐line PRRT (11.0 months vs 28.0 months; P = .383). Severe adverse events included lymphocytopenia (20.0%) and thrombocytopenia (5.7%). Myelodysplastic syndrome occurred in one case. Conclusion: PRRT was effective and safe for Japanese patients with advanced NETs. PRRT was equally effective as front‐line and late‐line treatment. Abstract : Highlight Peptide receptor radionuclide therapy with radiolabeled somatostatin analogs is an innovative treatment for advanced somatostatin‐positive neuroendocrine tumors. This retrospective study by Kobayashi and colleagues, which constitutes the first report of peptide receptor radionuclide therapy for Japanese patients with advanced neuroendocrine tumors, demonstrated good efficacy and safety in the Japanese patient cohort.