Letter to the editor concerning the article 'Safety of vaccines administration in hereditary fructose intolerance'. Issue 8 (3rd August 2021)

• Record Type: Journal Article
• Authors: Saborido-Fiaño, Rebeca; Martinón-Torres, Nazareth; Crujeiras-Martinez, Vanesa; Couce, Maria Luz; Leis, Rosaura
• Is Part Of: Human vaccines & immunotherapeutics. Volume 17:Issue 8(2021)
• Page Start: 2593
• Page End: 2594
• Publication Date: 2021-08-03
• Subjects: Rotavirus -- vaccine -- safety -- hereditary fructose intolerance; Vaccines -- Periodicals; 615.372
• DOI: 10.1080/21645515.2021.1891816
• Languages: English
• ISSNs: 2164-5515

Abstract

ABSTRACT: The most important approach for the management of hereditary fructose intolerance is a strict avoidance of fructose, sucrose and sorbitol from the diet and medications. A safe threshold of 2.4 mg/kg/dose was recently established by the Instituto Superiore di Sanità of Italy for both oral and parenteral routes, thus shouldering a safe administration of a majority of vaccines in these patients. This would not include, Rotarix® pre-established oral suspension and Rotateq® vaccines, which are indeed contraindicated. Moreover, Rotarix® white powder and solvent for oral suspension would only be safely administered at a weight above 9.3 kg. Overall, these recommendations to avoid rotavirus vaccination are difficult to implement because these vaccines are given during exclusive breastfeeding, prior to fructose-containing food introduction.