In-hospital outcomes of COVID-19 infection in patients with underlying cardiovascular disease. (2nd September 2021)

• Record Type: Journal Article
• Authors: Changal, Khalid; Mack, Sean; Veria, Spiro; Paternite, David; Bashir, Rehana; Patel, Mitra; Ali, Muhammad; Nazir, Salik; Mir, Tanveer; Sheikh, Mujeeb; Ramanathan, P. Kasi
• Is Part Of: Expert review of cardiovascular therapy. Volume 19:Number 9(2021)
• Page Start: 871
• Page End: 876
• Publication Date: 2021-09-02
• Subjects: COVID-19 -- cardiovascular disease -- myocardial injury; Cardiovascular agents -- Research -- Periodicals; 616.12061
• DOI: 10.1080/14779072.2021.1970532
• Languages: English
• ISSNs: 1477-9072

Abstract

ABSTRACT: Background: The effects of cardiovascular comorbidities on outcomes in COVID-19 hospitalized patients has not been well studied. Methods: This is a hospital-based study evaluating the effects of CVD on the outcomes in patients admitted with COVID-19. Clinical outcomes were studied in patients with and without CVD. Results: Eighty-seven patients had CVD, and 193 patients had no history of CVD. Ischemic heart disease was the most common CVD (63%). When compared with patients with no CVD, those with CVD had higher mortality (29% vs 9%, p < 0.001), discharge to a skilled nursing facility (SNF) (36% vs 15%, p < 0.001), and change of code status to 'do not resuscitate' (41% vs 14%, p < 0.001). The odds for mortality were high with ischemic heart disease (OR 3.6, 95% CI 1.8–7.3, p < 0.001), and systolic heart failure (OR 3.8, 95% CI 1.2–12.3, p = 0.02). Patients in the CVD group were more likely to have incident atrial fibrillation (22% vs 3%, p < 0.001), type 2 Mi (17% vs 6%, p = 0.002), high BNP (57% vs 14%, p < 0.001), acute kidney injury (64% vs 29%, p < 0.001), and any type of circulatory shock (27% vs 12%, p = 0.001). Conclusion: CVD is associated with increased mortality, myocardial injury, arrhythmias, and discharges to an SNF.